Semaglutide: Uses, Side Effects, & FAQs

How Semaglutide Works

Semaglutide is a medication that mimics a natural hormone in the body called GLP-1 (glucagon-like peptide-1), which plays a key role in regulating blood sugar, appetite, and digestion.¹

By mimicking GLP-1, Semaglutide slows down the rate at which food is digested, increases feelings of fullness, and reduces cravings, which can lead to lower overall food intake.

Semaglutide also helps the pancreas release insulin in response to meals, which supports better blood sugar control, particularly for individuals with type 2 diabetes.

Through these combined effects, Semaglutide aids in gradual and sustained weight loss while improving metabolic function. 

It is a long-acting medication, typically taken either once a week in injectable form or once daily as an oral tablet or capsule, depending on the prescribed formulation.

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How to Take Semaglutide

Semaglutide is available in two forms:

1. Oral capsules or tablets

• Taken once daily, ideally at the same time each day
• Can be taken with or without food
• Avoid taking it immediately after large meals to reduce digestive discomfort

2. Injectable solution

• Taken once a week, on the same day each week
• Injected under the skin in the thigh, stomach, or upper arm

The dose may be started low and increase after at least a month to improve tolerance and iminimize side effects. Never adjust your dose without receiving medical guidance.

If a dose is missed, follow your healthcare provider’s instructions, do not take double doses to compensate.

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Who Can Take Semaglutide

Semaglutide is primarily intended for adults who are overweight or obese and need medical support for weight management.

You may be a candidate for Semaglutide if:

• You have a body mass index (BMI) of 25 or higher.²
• You have difficulty losing weight through diet and exercise alone.
• You require additional help in managing appetite or portion control.

Semaglutide is also used in patients with type 2 diabetes to help improve blood sugar levels, though it is not a replacement for insulin.³

Semaglutide is not recommended for:

• Individuals with type 1 diabetes
• Those with a personal or family history of medullary thyroid cancer
• Patients with a history of pancreatitis
• Pregnant or breastfeeding individuals
• Anyone under 18 years of age

A proper medical assessment is necessary before starting Semaglutide to ensure it is safe and appropriate for your health condition.

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Side Effects of Semaglutide

Like any medication, Semaglutide may cause side effects. These are usually mild and temporary, especially during the first few weeks or when increasing the dose.

Common side effects include:

• Nausea
• Fatigue
• Stomach pain or bloating

Starting with a low dose and gradually increasing it can help reduce these effects. If any side effects become severe or don’t go away, contact your doctor immediately.

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Medicines You Should Not Use with Semaglutide

Some medications may interact with Semaglutide, affecting how it works or increasing the risk of side effects.⁴

Avoid using Semaglutide with:

• Other GLP-1 receptor agonists (such as liraglutide or dulaglutide)
• Weight loss drugs, unless prescribed together by a physician
• Insulin or sulfonylureas, without dose adjustment and monitoring

Use caution when combining with:

• Oral medications that require fast absorption (Semaglutide slows digestion)
• Certain blood pressure, cholesterol, or antibiotic medications

Always provide your doctor with a complete list of medications and supplements you are taking.

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Frequently Asked Questions (FAQs)

How does Semaglutide work?

It mimics the GLP-1 hormone to help control appetite, slow digestion, and support weight loss.

How should Semaglutide be taken?

Semaglutide is usually sold as a weekly injectable or as a capsule taken daily. In both cases, semaglutide should either be swallowed or administered at the same time daily or weekly, with or without food, as prescribed.

What are the common side effects of Semaglutide?

Nausea, stomach discomfort, constipation or diarrhea, low appetite, and fatigue. Most are mild and temporary.

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*The information provided on this platform is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.